A cura di Alessandra Russo. Specialista in Tossicologia Medica. Messina
|
Principio attivo |
Effetto |
|
Acido aminolevulinico (1) |
Possibile aumento del rischio di reazioni cutanee fototossiche |
|
Atazanavir (2) |
Possibile riduzione delle concentrazioni plasmatiche di atazanavir |
|
Ferro (3-7) |
Possibile riduzione dell’efficacia della minociclina e del ferro |
|
Penicilline (8) |
Possibile riduzione dell’efficacia antibatterica |
|
Vitamina A (9) |
Possibile aumento del rischio di pseudotumor cerebri (ipertensione endocranica benigna). |
Bibliografia
- Product Information: GLEOLAN powder for oral solution, aminolevulinic acid HCl powder for oral solution. NX Development Corp (per FDA), Miami, FL, Jun, 2017.
- Di Cenzo R, et al. Effects of minocycline and valproic acid coadministration on atazanavir plasma concentrations in human immunodeficiency virus-infected adults receiving atazanavir-ritonavir. Antimicrob Agents Chemother 2008; 52: 3035-3039.
- Gothoni G, et al. Iron-tetracycline interaction: effect of time interval between the drugs. Acta Med Scand 1972; 191: 409.
- Greenberger NJ. Absorption of tetracyclines: interference by iron. Ann Intern Med 1971; 74: 792.
- Neuvonen PJ, Turakka H. Inhibitory effect of various iron salts on the absorption of tetracycline in man. Eur J Clin Pharmacol 1974; 7: 357-360.
- Neuvonen PJ, et al. Interference of iron with the absorption of tetracycline in man. Br Med J 1970; 4: 532-534.
- Neuvonen PJ. Interactions with the absorption of tetracyclines. Drugs 1976; 11: 45-54.
- Moellering RC. Rationale for use of antimicrobial combinations. Am J Med 1983; 75 (2A): 4-8.
- Moskowitz Y, et al. Pseudotumor cerebri induced by vitamin A combined with minocycline. Ann Ophthalmol 1993; 25: 306-308.
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