A cura di Simona Lucchesi. UOSD Farmacologia Clinica. AOU “G. Martino” Messina
|
Principio attivo |
Effetto |
|
Aprepitant (1) |
Aumento delle concentrazioni sieriche di quetiapina |
|
Warfarin (2-4) |
Rischio di sanguinamento e aumento dell’INR |
Bibliografia
- Verwimp-Hoeks MP. Aprepitant quetiapine: a clinically significant drug interaction in a patient treated for head and neck cancer. Ann Oncol Mar 2012; 23: 801-802.
- Rogers T, et al. Possible interaction between warfarin and quetiapine (letter). J Clin Psychopharmacol 1999; 19: 382-383.
- Product Information: COUMADIN(R) oral tablets, intravenous injection powder lyophilized for solution, warfarin sodium oral tablets, intravenous injection powder lyophilized for solution. Bristol-Myers Squibb Company (per FDA), Princeton, NJ, Oct, 2011.
- Yang FW, Liang CS. Multiple intracerebral hemorrhages in an elderly patient after adding quetiapine to a stable warfarin regimen. Gen Hosp Psychiatry 2011; 33: 302.
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