Fascite eosinofila indotta da semaglutide

A cura di Alessandra Russo. Specialista in Tossicologia Medica. Messina

Caso clinico (1)

Una donna di 42 anni aveva iniziato a manifestare mialgia associata a edema agli arti due settimane dopo aver iniziato un trattamento con semaglutide per via sottocutanea al fine di perdere peso.

Alla visita la frequenza cardiaca era 75 battiti/minuto, la pressione 105/70 mmHg e la frequenza respiratoria 18 atti/minuto.

Gli esami di laboratorio evidenziarono una positività agli anticorpi antiperossidasi tiroidea e livelli elevati di IgE.

Venne effettuata una risonanza agli arti inferiori, che mostrò la presenza di un ispessimento lineare diffuso.

Fu fatta diagnosi di fascite eosinofila.

Il trattamento con semaglutide venne interrotto e la paziente venne trattata con metilprednisolone.

Nelle settimane successive si verificò una risoluzione completa dei sintomi, con normalizzazione della conta eosinofila e scomparsa dell’edema agli arti.

Una risonanza magnetica effettuata 4 mesi dopo evidenziò un netto miglioramento.

Le reazioni avverse più spesso riportate nei pazienti trattati con agonisti del recettore del glucagone-like peptide-1 (GLP-1), come la semaglutide, includono nausea, vomito e diarrea (2).

Raramente sono stati segnalati casi di pancreatite, insufficienza renale acuta e ipoglicemia (3-5).

Inoltre, sono stati riportati casi isolati di reazioni eosinofile (6-24).

Bibliografia

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